The area surrounding the wheels has massive impact on aerodynamics, it is a major focal point for even ICE trucks. Look at the air injection the manufacturers are putting into the fascia to try to get the air to go over the wheel well smoother.
I suppose anything is possible, but dollars to donuts says that any messing with that area is not going to be an improvement.
I noticed that the Lightning has plastic chip guards on the lower fenders there, I am betting for exactly that purpose. That is what they found to be the best aero answer for the truck, or chances are they would have done something differently.